Two major hypotheses have been suggested, a direct toxic injury to lung cells and an
Amiodarone, a primarily class III antiarrhythmic drug is one of the most commonly used drug in atrial Amiodarone-Induced Pulmonary Toxicity – A Frequently Missed Complication Abstract
MIPI can be driven by many mechanisms of lung injury, including direct DNA damage, alterations in alveolar cell signaling that enhance apoptosis or suppress cell proliferation, and T-cell–mediated
Abstract Amiodarone is an anti-arrhythmic drug widely used, but its administration can be associated with several adverse side-effects
Amiodarone is a powerful antiarrhythmic drug that can cause serious lung problems in up to 5% of patients
A known complication of Amiodarone therapy is Amiodarone induced Pulmonary Toxicity (APT)
“There have been reports of acute onset
, Haeckel T
The multidisciplinary consult concluded that the patient suffers either from autoimmune interstitial lung disease or drug induced lung injury
The increased risk of developing amiodarone-induced pulmonary fibrosis is directly related to the dose and the duration
From the study by Dusman et al
“There have been reports of acute onset (days to weeks) pulmonary injury in patients treated with A number of drugs have been reported as risk factors for acute lung injury (ALI) and ARDS
Three different mechanisms of amiodarone induced lung disease have been suggested: a direct toxic effect, an immune-mediated
DOI: 10
The clinical and radiologic manifestations of these drugs generally reflect the underlying histopathologic processes and include
Amiodarone is approved by the U
Less well known is amiodarone'spotential to cause acute lung damage, which can be severe or, occasionally, life-threatening
Lung injury that is induced by pneumotoxic agents gives rise to alveolitis and edema
2018 Dec 29 Objective: To study the clinical, pathologic and radiologic features of amiodarone-induced lung injury
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